What is the source of leukotrienes?

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Multiple Choice

What is the source of leukotrienes?

Explanation:
Leukotrienes come from arachidonic acid that is released from membrane phospholipids and then metabolized by the 5-lipoxygenase pathway in leukocytes, with mast cells being a key source. When mast cells are activated, phospholipase A2 frees arachidonic acid, which 5-LO converts into leukotrienes (such as LTC4, LTD4, and LTE4) that drive inflammatory responses and bronchoconstriction. Platelets mainly produce prostaglandins and thromboxanes via cyclooxygenase, not leukotrienes; histamine is released from mast cell granules as a different mediator; linoleic acid isn’t the direct substrate for leukotriene synthesis. Hence, the source is arachidonic acid in mast cells.

Leukotrienes come from arachidonic acid that is released from membrane phospholipids and then metabolized by the 5-lipoxygenase pathway in leukocytes, with mast cells being a key source. When mast cells are activated, phospholipase A2 frees arachidonic acid, which 5-LO converts into leukotrienes (such as LTC4, LTD4, and LTE4) that drive inflammatory responses and bronchoconstriction. Platelets mainly produce prostaglandins and thromboxanes via cyclooxygenase, not leukotrienes; histamine is released from mast cell granules as a different mediator; linoleic acid isn’t the direct substrate for leukotriene synthesis. Hence, the source is arachidonic acid in mast cells.

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