What is a major action of histamine in inflammation?

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Multiple Choice

What is a major action of histamine in inflammation?

Explanation:
Histamine released during acute inflammation acts on the microvasculature to cause rapid vasodilation and increased capillary permeability. It primarily does this by binding to receptors on the endothelium, making the vessel walls more permissive to fluid and proteins. The result is increased blood flow to the area and leakage of plasma into the tissue, forming exudate and resulting in edema. This immediate vasodilation and permeability change is the major action of histamine in inflammation. The other ideas—vasoconstriction, inhibition of exudate, or decreased edema—do not fit histamine’s well-established effect.

Histamine released during acute inflammation acts on the microvasculature to cause rapid vasodilation and increased capillary permeability. It primarily does this by binding to receptors on the endothelium, making the vessel walls more permissive to fluid and proteins. The result is increased blood flow to the area and leakage of plasma into the tissue, forming exudate and resulting in edema. This immediate vasodilation and permeability change is the major action of histamine in inflammation. The other ideas—vasoconstriction, inhibition of exudate, or decreased edema—do not fit histamine’s well-established effect.

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