Bradykinin is generated from which of the following sources?

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Multiple Choice

Bradykinin is generated from which of the following sources?

Explanation:
Bradykinin comes from a plasma protein produced by the liver, specifically high‑molecular‑weight kininogen. In the kallikrein–kinin system, the enzyme kallikrein cleaves this kininogen to release bradykinin. This makes the liver-synthesized plasma protein the source, not cellular mediators or lipid-derived pathways. Mast cells release histamine rather than bradykinin, arachidonic acid is the precursor for prostaglandins and leukotrienes, and platelets release other mediators but not the bradykinin precursor.

Bradykinin comes from a plasma protein produced by the liver, specifically high‑molecular‑weight kininogen. In the kallikrein–kinin system, the enzyme kallikrein cleaves this kininogen to release bradykinin. This makes the liver-synthesized plasma protein the source, not cellular mediators or lipid-derived pathways. Mast cells release histamine rather than bradykinin, arachidonic acid is the precursor for prostaglandins and leukotrienes, and platelets release other mediators but not the bradykinin precursor.

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